Increase in intracellular stress like DNA damage, oxidative stress, loss of proteostasis can make a healthy cell to become senescent cells. 

Senescent cells are known to increase with age in the body. The elimination of these cells has shown to increase the lifespan. My current project addresses to fundamental questions in the field of senescent cells:

1. What causes an increase in the senescent cells with age?
2. How does immune system maintain the senescent cells population in the body in young vs old?