A Post Doc who decodes AGING
I’m a postdoctoral researcher, working with Prof. Nir Yosef at the Weizmann Institute of Science. I’m studying how the immune system is involved in aging. My work combines systems immunology and computational biology, using advanced tools like spatial-single-cell transcriptomic and artificial intelligence to understand the cellular processes related to aging. I am curious about how our bodies change as we age and why disorders emerge.
A someone who finished his PhD
Before joining the Yosef Lab, I completed my Ph.D. in Molecular Cell Biology at the same Institute. My work answers three questions: How do senescent cells accumulate with aging? How does the senescent cell pathway regulate the immune response? And how do senescent cells change their nature along with aging? I was fortunate to work with amazing PIs, Prof. Valery Krizhanovsky and Prof. Uri Alon.
Aging- A conflict
As time flows, our bodies get old, and we approach a fate called “death.” Whether we sleep or are awake, the inner “aging clock” keeps ticking, accumulating damage from the tiniest molecules to our complex organs. This accumulation of damage results in a decline in functional performance, organ failure, and ultimate death. A fate that, paradoxically, is essential for the continuation of life itself.
While death marks the end for an individual, it is a renewal of the species. By removing older and less fertile organisms, death paves the way for new life and maintains the delicate balance of nature. This awareness of mortality makes us value and cherish the moments and bonds with our loved ones. On the other hand, aging can diminish the quality of life for many individuals. Additionally, the increasing number of older people presents unique challenges for healthcare systems, highlighting the need for innovative solutions to promote healthy aging.
Aging- A nature’s mystery
Aging is a beautiful process occurring in our body, from cells to tissues to the complex molecular pathways that communicate between them. The events in this process are not happening in isolation, and its outcome depends upon this intricate communication network. Finding out what’s exactly going on in the body with time and what is triggering it is a complex puzzle of nature, a puzzle that I’m fascinated by and people like me hope to solve.
Evolutionary instinct- Fight for survival of species
Understanding the complexity of this process is indeed scientifically interesting and fun. However, due to the evolutionarily-evolved inherent instinct to survive and reproduce, we are also driven to find biological pathways that can help us lower the burden of age-related diseases in our species.
I’m excited to share my research journey with you through this website. Feel free to explore my publications and ongoing projects. I am always up for discussions on aging and getting to know other people who are working on it. Most welcome to say hi to me.
Email: amit.aging@gmail.com
mechanism of aging 