Tiny Tweaks, Big Bangs?

Perturbation to the system can result in a transition from one state to another. Such a transition may have a positive or a negative effect, depending on who is perceiving it and what system it is.
This perturbation can be classified as

  • Gradual and small perturbation
  • Large perturbation

It is not surprising that a large perturbation to a system can result in sudden transition from one state to another. For example, you are sleeping and someone comes and shout your name, sudden transition from state of sleep to wakefulness.

Mysterious and most interesting kind of transition is when gradual small perturbation to system can result in sudden transition from one state to another. A clear lake can shift to turbid lake within few days for the gradual small increase in nutrient load in lake. Upto a threshold of nutrient, a lake remain clear but the same small increase in threshold, lake will shift to turbid lake. And its not easy to achieve the state of clear lake by reducing the same amount of nutrient.
Ecological system such as African savanna sudden shift from grassland to tropical forest for gradual increment in rain or other factors.

In some transitions, it is not possible to achieve a previous state by taking some step back. The system requires a very large cost to achieve its previous state.

For example, play this game, incline yourself as much as you can, a threshold point comes when the body loses its balance and fall down. If you want to achieve the same inclination that was before threshold point. You have to stand again and repeat the process.

The only way to prevent such transitions is by taking precautionary steps at a sufficient pace before the threshold point.

Why to work on aging?

After an age we observe decline in function of our body, increase in vulnerability to many diseases such as myopathies (loss of muscles), organ pathology (kidney failure), heart attack, Alzheimer’s disease and many more diseases. This is characterized as aging.
Continuous advancement in medical science has been increasing the life-expectancy of humans. Hence, increasing the population of old age people. It is as important to find the preventions and cures for diseases that occur in old people as it is for young people.

Vulnerability to many diseases like Alzheimer’s, cardiac dysfunction, or other age-related disorders increases as we age. This raises a possibility that there might be some common underlying mechanism that causes most of such diseases. It is interesting to explore this possibility by revealing the mechanism of aging. Hopefully, this may enable us to prevent age-associated diseases by taking action at the primitive cause.